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Mitochondrial DNA (mtDNA) is a compact, double-stranded, circular molecule with a length of 16,569 bp. mtDNA typically contains about 37 genes, including 22 tRNAs and 2 rRNAs. The instability and variation of mtDNA is increasingly recognized as an important cause of a range of human diseases, such as Alzheimer's disease, Parkinson's disease, colorectal cancer, Kearns-Sayre syndrome, and so on. The ratio of normal to mutant mtDNAs within cells is an important factor that not only determines whether the mutations cause disease, but also relates to penetrance, the severity of the phenotype, and clinical presentation. Given the importance of environmental impact on Mitochondrial DNA (mtDNA) and its association with an array of human diseases, the investigation of a complete mtDNA sequence will contribute to clinical studies and develop new therapies for related diseases.
Here, we are proud to offer amplification-free, full-length sequencing of linearized mtDNA using PacBio SMRT technology and its advanced Sequel II system. We are able to provide a complete end-to-end human mtDNA sequencing solution to serve our clients' specific projects in an accurate, high-throughput, customized, and cost-effective manner.
CD Genomics is a leading global life sciences company, and we continue to expand our services and improve our existing resources to help scientists accelerate their research and support their careers. One of our goals is to generate reference-quality assemblies in diverse populations to better help scientists understand the complexity of human health and disease. For more information on how we can help you, please feel free to contact us.