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Bacterial plasmids have been widely sequenced and serve as an essential tool in modern molecular biology research. CD Genomics is proud to offer full-length plasmid sequencing services based on two sequencing strategies, including the PacBio SMRT sequencing platform, and a combined Illumina sequencing and Oxford Nanopore Technologies (ONT) Nanopore sequencing strategy. Our services are available to meet the specific needs of our clients. Based on accuracy and affordability, our experts will provide them with the most suitable strategy to achieve their research goals.
Plasmids are genetic materials that have the ability to replicate independently outside the bacterial chromosome. Most plasmids are loop-closed, but linear dsDNA exists, ranging in size from 5 to 500kb. Although smaller than chromosomes, plasmids are important genomic components, providing the bacterial host with additional genetic material that is important for its survival and adaptation. Plasmids carry genetic information that can confer certain specific phenotypic traits such as fertility, drug resistance, pathogenicity, and metabolic alterations to the host bacteria and facilitate intra/interspecies gene flow.
Next-generation sequencing (NGS) technologies (short-read sequencing) have been widely applied to perform whole-genome analysis. However, assembling accessory regions of the genome using short-read NGS data is a challenge. Long sequence sequencing, including PacBio SMRT sequencing and ONT nanopore sequencing, can generate long sequence sequences, which have great advantages for genome assembly, especially plasmid assembly.
To obtain complete and accurate plasmid information, researchers and professionals choose CD Genomics. Our service workflow is robust and powerful and is capable of recovering small plasmid sequences from complex microbiomes. We promise that each plasmid is fully sequenced by long reads with a high level of consistent accuracy. Please don't hesitate to contact us. We've got everything covered for your needs and are ready to assist.